Last update
5/20/2025
Research Authors

Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.3
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.6
Supplement Facts
Serving Size:  1 Softgel
Amount Per Serving
%DV
Vitamin A (from fish [liver] oil, retinyl palmitate)
3,000 mcg
333%

Top Medical Research Studies

We examined a case of a 4-year-old boy who experienced severe bone pain and related symptoms after taking high doses of vitamin A for three months. Despite typical liver-related complications usually associated with vitamin A toxicity, he presented with significant musculoskeletal issues and skin changes. Following the discontinuation of vitamin A, the boy showed a remarkable recovery within two months. This case highlights that excessive vitamin A intake can lead to serious bone pain and other health problems, though he did not develop liver disease as expected.
Read More
7
ATRA shows mixed effects on pain
We explored the effects of all-trans retinoic acid (ATRA) when combined with dexamethasone and alpha-interferon in treating advanced multiple myeloma. Out of 10 treated patients, eight completed the regimen.

Notably, three experienced a stable plateau phase with improvement in their overall performance and relief from bone pain. However, only two showed a lasting partial response, while three patients did not improve.

Thus, while there was some positive impact on bone pain, further research is needed to confirm these findings and assess ATRA's full potential.
Read More

Most Useful Reviews

6
Reduced bone pain
12 people found this helpful
It may be beneficial for the gastric lining. My stomach is sensitive, and I experience discomfort when drinking green or oolong tea, and I cannot take headache medication alongside Mucosta. However, the late-waking and sleeping issues have vanished, and my bone pain has almost disappeared. I wish I had started this sooner. Additionally, I've noticed a significant reduction in the use of eye drops, with no rust on my contacts.
Read More
0
Bone pain precautions
3 people found this helpful
Be cautious with vitamin A as excessive intake can lead to serious side effects like bone pain, liver damage, and headaches. Long-term use of over 10,000 mcg daily can be harmful. If pregnant or planning to conceive, consult your doctor due to the risk of birth defects associated with excess vitamin A. Careful management of supplements, considering interactions with other vitamins, is crucial for avoiding adverse effects.
Read More
6
Bone pain treatment
1 people found this helpful
Vitamin A acts as an antioxidant that supports the immune system, benefits bone tissue, the reproductive system, vision, and skin. It reduces TSH synthesis in the pituitary gland while enhancing iodine absorption by the thyroid, which is vital in treating hypothyroidism, particularly in relation to bone pain. It is essential not to exceed 3000 IU per day if you smoke. Take vitamins to look good and feel healthy!
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.3
  • All Researches
We examined a case of a 4-year-old boy who experienced severe bone pain and related symptoms after taking high doses of vitamin A for three months. Despite typical liver-related complications usually associated with vitamin A toxicity, he presented with significant musculoskeletal issues and skin changes. Following the discontinuation of vitamin A, the boy showed a remarkable recovery within two months. This case highlights that excessive vitamin A intake can lead to serious bone pain and other health problems, though he did not develop liver disease as expected.
Read More
7
ATRA shows mixed effects on pain
We explored the effects of all-trans retinoic acid (ATRA) when combined with dexamethasone and alpha-interferon in treating advanced multiple myeloma. Out of 10 treated patients, eight completed the regimen.

Notably, three experienced a stable plateau phase with improvement in their overall performance and relief from bone pain. However, only two showed a lasting partial response, while three patients did not improve.

Thus, while there was some positive impact on bone pain, further research is needed to confirm these findings and assess ATRA's full potential.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 3 Reviews
7.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
6
Reduced bone pain
12 people found this helpful
It may be beneficial for the gastric lining. My stomach is sensitive, and I experience discomfort when drinking green or oolong tea, and I cannot take headache medication alongside Mucosta. However, the late-waking and sleeping issues have vanished, and my bone pain has almost disappeared. I wish I had started this sooner. Additionally, I've noticed a significant reduction in the use of eye drops, with no rust on my contacts.
Read More
0
Bone pain precautions
3 people found this helpful
Be cautious with vitamin A as excessive intake can lead to serious side effects like bone pain, liver damage, and headaches. Long-term use of over 10,000 mcg daily can be harmful. If pregnant or planning to conceive, consult your doctor due to the risk of birth defects associated with excess vitamin A. Careful management of supplements, considering interactions with other vitamins, is crucial for avoiding adverse effects.
Read More
6
Bone pain treatment
1 people found this helpful
Vitamin A acts as an antioxidant that supports the immune system, benefits bone tissue, the reproductive system, vision, and skin. It reduces TSH synthesis in the pituitary gland while enhancing iodine absorption by the thyroid, which is vital in treating hypothyroidism, particularly in relation to bone pain. It is essential not to exceed 3000 IU per day if you smoke. Take vitamins to look good and feel healthy!
Read More

Frequently Asked Questions

6
Reduced bone pain
12 people found this helpful
It may be beneficial for the gastric lining. My stomach is sensitive, and I experience discomfort when drinking green or oolong tea, and I cannot take headache medication alongside Mucosta. However, the late-waking and sleeping issues have vanished, and my bone pain has almost disappeared. I wish I had started this sooner. Additionally, I've noticed a significant reduction in the use of eye drops, with no rust on my contacts.
0
Bone pain precautions
3 people found this helpful
Be cautious with vitamin A as excessive intake can lead to serious side effects like bone pain, liver damage, and headaches. Long-term use of over 10,000 mcg daily can be harmful. If pregnant or planning to conceive, consult your doctor due to the risk of birth defects associated with excess vitamin A. Careful management of supplements, considering interactions with other vitamins, is crucial for avoiding adverse effects.
6
Bone pain treatment
1 people found this helpful
Vitamin A acts as an antioxidant that supports the immune system, benefits bone tissue, the reproductive system, vision, and skin. It reduces TSH synthesis in the pituitary gland while enhancing iodine absorption by the thyroid, which is vital in treating hypothyroidism, particularly in relation to bone pain. It is essential not to exceed 3000 IU per day if you smoke. Take vitamins to look good and feel healthy!
We examined a case of a 4-year-old boy who experienced severe bone pain and related symptoms after taking high doses of vitamin A for three months. Despite typical liver-related complications usually associated with vitamin A toxicity, he presented with significant musculoskeletal issues and skin changes. Following the discontinuation of vitamin A, the boy showed a remarkable recovery within two months. This case highlights that excessive vitamin A intake can lead to serious bone pain and other health problems, though he did not develop liver disease as expected.
7
ATRA shows mixed effects on pain
We explored the effects of all-trans retinoic acid (ATRA) when combined with dexamethasone and alpha-interferon in treating advanced multiple myeloma. Out of 10 treated patients, eight completed the regimen.

Notably, three experienced a stable plateau phase with improvement in their overall performance and relief from bone pain. However, only two showed a lasting partial response, while three patients did not improve.

Thus, while there was some positive impact on bone pain, further research is needed to confirm these findings and assess ATRA's full potential.

References

  1. Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102:556. 10.1136/archdischild-2016-310631
  2. Musto P, Sajeva MR, Sanpaolo G, D'Arena G, Scalzulli PR, et al. All-trans retinoic acid in combination with alpha-interferon and dexamethasone for advanced multiple myeloma. Haematologica. 1997;82:354.
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